EPITHELIAL BARRIER OF THE COLON IN NORMAL AND ULCERATIVE COLITIS

Abstract

This article is devoted to the morphofunctional evaluation of diffuse endocrine cells of the mucosa of the digestive tract. Endocrine cells of the gastrointestinal tract secrete a number of biologically active substances with a wide range of both local and systemic effects, which ultimately affect the growth and development of the organism. Morphological changes in the diffuse endocrine system of the digestive tract of the offspring of female rats with chronic liver damage have been studied by many scientists. Other authors have considered characteristic changes in the diffuse endocrine system of the digestive tract of the offspring of female rats with chronic lesions in the intestine. One of the most important in modern morphology are the questions of genesis, differentiation, structure and cytophysiology of tissues under conditions of normal functioning and under pathology. The study of these problems provides an opportunity for further development of cytology, histology, endocrinology, embryology and deeper understanding of processes occurring in clinical pathology. In this respect the questions connected with formation of endocrine apparatus of large intestine during phylo- and ontogenesis, structure and differentiation of human and vertebrate animal intestinal epithelium endocrine cells in norm, under experimental influence and some kinds of gastrointestinal tract (GIT) pathology are of great interest.